Research Use Only: Intended for in-vitro laboratory research only. Not for human or animal consumption. This page provides mechanistic and research-context information only — it does not constitute dosing, administration, or medical advice of any kind.
MOTS-C
A mitochondria-encoded peptide that's studied for its effects on AMPK signaling and insulin receptor pathways.
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. It is studied as a mitochondrial-derived signaling peptide in AMPK-pathway and cellular-metabolism research.
Encoded by mitochondrial DNA
Research shows AMPK pathway activation
Important for metabolic signaling
Key longevity research target
- Mechanism
Scientific Mechanism
This class of compounds targets mitochondrial function, oxidative stress pathways, and cellular senescence markers. Mechanisms studied include mitochondrial membrane stabilization, sirtuin-pathway activation via NAD+ availability, and telomerase-related signaling — all active areas of longevity and cellular-aging research.
- Mechanism detail
How It Works
MOTS-C works through mitochondrial signaling:
ampk:
Activates AMPK pathway
metabolism:
Modulates metabolic signaling
insulin:
Affects insulin receptor pathways
- Research evidence
What the Research Shows
Metabolic:
- Longevity & Mitochondrial Research
Research Applications
Studied in in-vitro models for metabolic regulation, receptor pathway activation, and cellular energetics.
- Research notes
Key Research Points
- Investigated for mitochondrial signaling, metabolic regulation, and AMPK activation.
- Mitochondrial-derived peptide (CAS 1627580-64-6)
- Lot-level documentation and Certificate of Analysis
Common Questions
- Laboratory context
Research Considerations
- For in-vitro laboratory research use only
- Not for human or animal consumption
- Verify identity and purity against the lot Certificate of Analysis
- Handle with standard laboratory PPE and aseptic technique
- Storage & handling
Stability Protocol
Lyophilized powder: store at -20°C with desiccant, protected from light. Reconstituted solution: refrigerate at 2–8°C, discard after 28–30 days or if cloudiness/particulate appears.
- Reconstitution math
Concentration Calculator
Concentration math only — for research reference. Not dosing guidance.
- Verification
Certificate of Analysis
Research Use Only: Intended for in-vitro laboratory research only. Not for human or animal consumption. This page provides mechanistic and research-context information only — it does not constitute dosing, administration, or medical advice of any kind.